بشم الله الحمد لله

This week in OLM 2 some interesting topics: breastfeeding and triptans, badly behaved boys and their mums, breastfeeding and triptans and careful with zoledronic acid and impaired renal function. Also more Clopidogrel interfering drugs, risk of developing asthma, chronic cough and montelukast, wound cleaning with tap water and finally a nice set of questions when doing a paper review.

BREASTFEEDING & TRIPTANS: Sumatriptan is data wise best.
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03-04-2010


NEGATIVE BEHAVIOUR & BOYS: Attachement to mothers associated with less negative outcomes. Nice quote: “Dr. Rosenfeld. “We’ve known for a long time that it’s not material things but feelings that count,” he said. He added that these feelings are demonstrated in different ways in different cultures. “In some societies, a kid knows he’s loved just by a slight raise of an eyebrow.””
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03-04-2010


ZOLEDRONIC ACID & RENAL FUNCTION: Measure renal function before infusion. Do not use if CrCl<35
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03-04-2010


CLOPIDOGREL & CYP2C19 INHIBITORS: Apart from Omeprazole here are another few drugs to think about that may effect clopidogrel according to the MHRA “CYP2C19 inhibitors include fluvoxamine, fluoxetine, moclobemide, voriconazole, fluconazole, ticlopidine, ciprofloxacin, cimetidine, carbamazepine, oxcarbazepine, and chloramphenicol)”
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03-04-2010


RISK OF ASTHMA: Role of rhinovirus infections in early life. If Rhinovirus + wheeze at age 3 then OR(Asthma)=32. Trying to prevent asthma with Inhaled Cortico Steroids was not shown to work (PEAK & PAC studies) “Wheezing illnesses caused by HRV in early childhood clearly identify children at increased risk of childhood asthma.”
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30-03-2010


ACNE Rx: In a nutshell. Combining BP (Benzoyl peroxide) & topical antibiotics +/- Topical retinoids works well. Inflammatory Acne may need short term low dose oral steroids.
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30-03-2010


WOUND CLEANING: Cochrane review tap water is as good as isotonic saline. Interestingly no evidence to say cleaning wounds actually reduces infection! “There is no evidence that using tap water to cleanse acute wounds in adults increases infection and some evidence that it reduces it. However there is not strong evidence that cleansing wounds per se increases healing or reduces infection. ”
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30-03-2010


COUGH IN PAEDS: Cochrane review no evidence to support use of Montelukast. [Non-specific cough is defined as non-productive cough in the absence of identifiable respiratory disease or known aetiology. ]
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30-03-2010


PAPER REVIEW – Nice set of tips on how to discuss a paper.
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30-03-2010


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