Dr Taqi

Archive for February 2009

Do PPIs cancel Clopidogrel benefits?

Posted by: drtaqi on: February 2, 2009

A Canadian based population study looked at patients who had an MI, were given Clopidogrel +/- a PPI. They found giving a PPI (omeprazole, lansoperazole, rabeprazole ) that inhibits Cytochrome p450 2C19 is associated with a OR of 1.4 of a recurrent MI in the first 30 days following an MI. Pantoprazole did not have this [...]