Posted by: drtaqi on: November 6, 2009
بسم الله
Next time someone comes for a regular flu shot think: heterosubtypic immunity.
What does that mean?
Vaccinations give narrow immunity.
Natural infections give wider immunity (heterosubtypic immunity).
So?
Being infected by influenza A – naturally – give protection against realetd species i.e. possibly H1N1.
But being vaccinated stops you from getting natural infection and hence you are left without this additive protective effect i.e. not good if it’s a killer pandemic.
Is this confirmed?
Experimental evidence is pointing to it (animal studies). Whether it holds true is unclear as no one has checked to see if the chidren who died from a pandemic strain such as H1N1 had more regular Influenza A vaccinations then those who did not.
If you want read more here.
Posted by: drtaqi on: July 7, 2009
AOA Dr. Taqi.
I have a couple of questions which may sound very trivial but they are often asked in the viva.
1. How do you differentiate between a Viral Infection and a Bacterial Infection?
2. What is the optimal duration of antibiotic therapy?
Dr. Hamza
Thank you for the question and walaikumsalaam Dr Hamza,
As usual these questions are looking for a method of response rather than a particular response. There is no absolute right or wrong. I would fashion my answer as follows:
Differentiating a bacterial from a viral infection is a matter of probability rather than certainty. The only true way of differentiating the two would be to run expensive, time consuming tests such as body fluid cultures, PCR for viral DNA. Even with the aid of such tests we would have the additional problem of working out the relevance of any results. Not everything cultured is the cause of an infection, throat swabs and beta hemolytic streptococcus being a good case in point.
In a clinical setting I would say to the patient, ‘ We can’t tell the difference with 100% surety. But we can make an educated guess based on probability. Most healthy people when having simple infections such as sore throats usually have viral illnesses. It takes the production of antibodies directed against the virus to destroy the virus. This takes 3 days (reactivation of Plasma cells with a memory) if you have been exposed in the past and it will take about 5-7 days if this is a new virus. It would thus be reasonable to wait for a period of 7 days and let the body do its natural work. If you find the infections gets significantly worse especially around day 3-4 this could imply a secondary bacterial infection in which case I would like you to come back for a review. If you continue to be unwell beyond 7 days I would like to review earlier or at any time where you are significantly worried or concerned by new symptoms.
Optimum duration of antibiotics:
The examiners are looking I would have thought for awareness of a spectrum of answers from one day as in bacterial vaginosis and a single dose metronidazole regime, to three days for uncomplicated UTIs to many months in cases of bacterial endocarditis to continuous for paediatric patients with recurrent UTIs. Other factors that you would take into account are the particular circumstances of the patient (elderly, immunocompromised), social points (children going to school, working people), patient preference and compliance. They may then quiz you on how long you would give an antibiotic before changing it, it may be worth while checking what the latest evidence is on this but from the top of my memory 2 – 3 days should result in some improvement, a lack of any improvement, worsening of condition should prompt a revaluation of the patient and the questions to answer: is the antibiotic working, is it viral, have I got the diagnosis wrong.
Hope that gives you some ideas on tackling these questions.
Posted by: drtaqi on: June 8, 2009
I came across a male patient with these odd purpuric lesions which where pigmented on his legs. This was 3 months after starting Metformin for diabetes. Not too sure what was going on I sent him to see our dermatologist and a diagnosis of Pigmented Purpuric Dermatitis was made.
In essence it is a capillaritis with T cell inflitration of unknown origin. If the medication is suspected stopping it for many months is recommended. They can dissapear in time or just hang around for many years. Steroids are not useful except for any itching. They look like this (courtesy of Derm Net) and you can read more about it here.
Posted by: drtaqi on: February 2, 2009
A Canadian based population study looked at patients who had an MI, were given Clopidogrel +/- a PPI. They found giving a PPI (omeprazole, lansoperazole, rabeprazole ) that inhibits Cytochrome p450 2C19 is associated with a OR of 1.4 of a recurrent MI in the first 30 days following an MI. Pantoprazole did not have this association and is the single PPI that does not inhibit CYP 450 2C19. This effect was not noted with H2 antagonists.
Clopidogrel is a pro-drug converted to its active form by the enzyme CYP 450 2C19. This enzyme which sits inside hepatic cells in the mitochondira and the endoplasmic reticulum busily adds an extra oxygen to the molecules its processes. The interesting thing is according to the wikipedia entry 15-20% of Asians have poor CYP 450 2C19 activity! So will it change my practice? Probably early days yet, populations studies are open to errors, everyone will call for a RCT (especially the companies that make PPIs), and pantoprazole is a sensible choce at least for the first 30 days while we try and work out whether this study is replicated by others. The other important question is: are 15-20% of Asians with poor CYP 450 2C19 activity benefiting from Clopidogrel?
Posted by: drtaqi on: January 30, 2009


Dr Stephen Norod - lead researcher
6 year prospective Canadian study following 1492 women in 365 families. All negative for BRCA1 and 2 mutations. Families followed up had 2 or more breast cancer diagnosis under 50y or 3 diagnosis at any age. 65 women developed breast cancer instead of the expected 15 expected for a population without a family history. Giving a four fould increased risk. Compared to the presence of BRCA1/2 mutations which confer a 7 fold increased risk.
Important to take the family history especially in women. Tamoxifen as prophylaxis? Quick research: it is a licenced indication ( 20mg qd x5 years according to epocaratesRx) but need to weigh up increased risk of stroke, PE and uterine malignancies. When is someone going to design an easy to use risk comparison tool?
Posted by: drtaqi on: January 10, 2009
Here is the final lecture list for this year’s seminar on Family Medicine organised by the King Faisal Hospital Jeddah’s Family Medicine department. An assortment of lectures reflecting the multiplicity of roles of the Family Physician.
Posted by: drtaqi on: January 6, 2009
In the i/nMRCGP you may get a patient that presents an ethical dilemma. The patient who has had a stroke and is now not fit to drive, should you breach your confidentiality and tell the authorities or not? A male patient who has come for a vasectomy because his female partner would like him to have one, they have one child. Is the patient acting autonomously, should you recommend this to the patient and so on.
When dealing with these patients it is good to have a framework to hang your questons on and the outcome of your consultation. A simple menmonic is the following one: ABCDE which stands for:
A – Autonomy: Is the patient acting because s/he wants to do it or is someone else pushing them into this action? Are you being forced to act because of the patient demand (‘Give me this drug doctor!’ Response: You have the right to ask for the medication but I as a doctor have the right based on my professional judgement to prescribe or not, to force me would be to breach my autonomy)
B – Beneficence: i.e. do good and not harm. I could give just refer the patient for his vasectomy but has he thoought about if the marriage goes wrong and he starts a new relationship that the vasectomy is very difficult to reverse and he may not have children in the future? If I agree to prescribe this drug to this patient then will this set a trend in the future i.e. harming other doctors and the doctor patient realtionship. If I prescribe the most expensive drug always first am I causing harm to society and the exchequer?
C – Confidentiality – Mother comes to speak about son, who is 19 – an adult. You have to maintain confidentiality. You could breach it with the permission of the other i.e. son happy to talk about his case with his mother, but if you sense this is difficult what do you do? Stick to keeping confidentiality in the abscence of permission. If two patients come together, you can always ask one to step out of the room for a short while, take permission from the other or ask any potentially embarassing questions: i.e. have you had sexual partners etc.
D – Duty : Duty of care to the patient, yourself (you do not have to be at the back and call of someone and you can let them know that there are certain procedures and hours and these should be followed), staff (sticking to general guidelines or working practices in your surgery), and society (resources, not misuring them etc.)
E – Equity – Being euqal with your resources between patients.
Posted by: drtaqi on: December 30, 2008
A primary care medical conference in Jeddah, as advertised below:
The Department of Family Medicine, King Faisal Specialist Hospital & Research Centre, Jeddah, Saudi Arabia (www.kfshrcj.org) is holding its 2nd Family Medicine Symposium on Jan 27 – 28, 2009, at the Inter-Continental Hotel Jeddah. This symposium is being held in collaboration with the Saudi Society for Family & Community Medicine – Jeddah (www.ssfcm.org/ssfcm_en/index.php) and the Joint Program for Family Medicine, Jeddah.
Last year at our first symposium, we had more than five hundred thirty registered participants, besides a large number of prominent national and international speakers.
This year’s symposium is primarily directed towards the family physicians and general practitioners. However, the symposium is open to residents, nurses, researchers and other allied health professionals. We plan to cover a wide variety of medical topics, including medical updates that would be of interest to our target audience.
We invite you to attend this symposium and benefit from knowledge sharing. International participants will have an excellent opportunity to closely observe the fascinating local culture and rich heritage in Saudi Arabia.
The hospital will arrange a business visa to enter Saudi Arabia but sufficient time should be given for this process which is relatively straight forward.
Posted by: drtaqi on: December 29, 2008
In the following table I have listed a natural flow for a consultation and the key ‘trigger phrases’ that you need to adopt. Of course your ‘trigger phrase’ may be different to the one table but make sure it is triggering the right OSCE domain. All the best with your exams!
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Patient consultation setting:
|
Verbal |
Body language |
OSCE Domains |
|
Introduce yourself |
Hi, I am doctor Abc. |
Smile, nod, lean forward slightly to show interest but look professional |
A: courtesy consideration |
|
Take a history |
How can I help you today? |
Again nod you head and look as you are interested in what the patient has to say, look at the patient not anywhere else! Listen carefully |
A: Full focused history |
|
Encourage the patient. Hunt for the hidden diagnosis if the history is nebulous or psychiatric. If the patient provides a problem assess their iedas by asking them what they think is the cause, they might think eczema is contagious hence they are not going out in which case you can address their worries or correct through education their ideas. If after 1 minute you can see they are rambling and they pause this is probably a heart sink patient and you need to ask what their expectations are so you can work out what they want you to do? |
You mentioned (pain/ walking difficulty/ dizziness / thirst/ chest discomfort / breathing problems etc), can you tell me a bit more about it? Is there anything else on your mind? Are you worried about anything else? [Concerns] What do you think is causing it? [Ideas]. What would you like me to do for you today? What would you like to see happen today? [Expectations] |
Listen for the cues, the role playing patients will give them and expect you to pick them up! Remember the patients will be talking in layman’s language. The actors will try and look uncomfortable or hesitate – this is a cue to a hidden agenda, they may avoid eye contact or say something like ‘There was something else but it’s not important’. |
B: sensitivity to patient, facilitates free expression of ICE (ideas, concerns and expectations)
C: Good communication skills
E: Considers implications for the patient and others. |
|
You have a diagnosis in mind, think is anything serious, ask the important questions, red flags, things that will sift important from less important. Think red flags: Upper GI: weight loss, dysphagia. Lower GI: Change in bowel habits >6w Resp: Weight loss, sweating at night, cough >2 weeks. Cauda equine lesion: weaknes, bladder bowel control loss, pain raditing to tip of toe etc. Check the NICE fast track referral guidelines! Ask the socio-economic impact of the problem. |
Back pain: Do you have numbness in between your legs. Any problems with passing urine such as difficulty controlling it? Clarify difficult questions. Is this affecting your life or work? Do you find it difficult to deal with the children? |
Use your fingers to demonstrate what you mean by in between. Try and use body language to help your questions. |
A: takes a history sufficient to exclude a serious condition. |
|
Examine appropriately, don’t do a full exam, concentrate on the bits you need, and don’t miss postural hypotension if they are dizzy! |
I would like to examine your back / hands is that okay? I will need you to (mention what you need them to do) |
Pause after asking permission! Demonstrate the exam procedure if simple with your own body, i.e. position your hands etc. |
A: Examines patient appropriately and efficiently. |
|
Diagnosis Make your diagnosis, and add 2 differentials if appropriate. If the diagnosis is obvious just state it and do not add differentials unless the patient asks could it be anything else. Don’t forget to rule out any concerns that patient had said at the beginning. Don’t forget to assess for understanding at the end by asking for any questions. |
Let me explain what I think, From what you have said and the exam I think you have A or B or C. I think A is likely but we will need to do some tests to work out if it is A or B or C. Let me explain what A is … You mentioned you were worried about skin cancer, I can reassure you that this is not related to skin cancer but is eczema. Do you have any questions? |
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C: Offers clear explanation of symptoms and diagnosis to the patient. |
|
Management Start with the least expensive (show correct resource management), and offer a couple of options quickly explain the pros and cons of each and then hand over to the patient. Be prepared to negotiate i.e. I want CBT and medication – say we have limited resources and we should try one and then the other |
For the depression we can use talking therapies or medications or herbal therapies. Talking therapies work as well but take time, tablets work quickly while herbal remedies can work but can also be unpredictable. What would you like to do? |
|
C: Negotiates management of patient. Involves them in decision.
D: Treats and investigates appropriately, offers range of options, safe prescribing. |
|
Summarise and Safety Net. Health promote – tag this on here. |
Let me summarise so I am sure I have explained things well: You have depression. We’ll treat it with an anti-depressant which is one tablet per day. I would like to review in one week to see how you are getting along. If you have any problems don’t hesitate to come back and see on the on call doctors or if it out of hours one of the out of hours services. Just one more thing I would like to add: have you had your cervical smear / do you smoke? (if they say yes) Could we please talk more about this, could you book an appointment in the next few weeks whenever is convenient? |
You could write down basic points on a sheet of paper and give them to the patient. Your prescriptions will be assessed so write fully and legibly. |
E: Arranges follow up requirements
E: Arranges health promotion. |
Posted by: drtaqi on: December 28, 2008
This is currently a recommendation in the USA and Canada across all trimesters, but the uptake of this vaccine in the USA is only 16% indicating reluctance amongst pregnant ladies and health professionals. I must admit to being one of the reluctant health professionals and decided to read up on the matter. An article in the Lancet Infectious Diseases reviewing influenza vaccine in pregnancy by Mak et al in January 2008 provided a very good summary of the data concerning this topic so far. It was titled “Influenza vaccination in pregnancy: current evidence and selected national policies” I have summarised the article in a Q & A format with my own comments in italics.